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NEW QUESTION: 1
Your patient is a 58-year-old male who presents with onset of severe substernal chest pain and shortness of breath. An ECG reveals an acute STEMI, and he is on his way to the cardiac catheterization suite for percutaneous coronary intervention.
Which of the following drugs used in acute coronary syndromes treated with PCI must undergo oxidation by hepatic P450 enzymes to an active form?
A. Clopidogrel
B. Warfarin
C. Eptifibatide
D. Aspirin
E. Ticlopidine
Answer: A
Explanation:
Explanation
Clopidogrel and ticlopidine are ADP receptor pathway inhibitors. The irreversible inhibition of the ADP- dependent pathway of platelet activation is thought to be the result of covalent modification and inactivation of the platelet P2Y ADP receptor. This receptor is coupled to the inhibition of adenylyl cyclase. Both drugs are prodrugs and undergo conversion to active metabolites in the liver. However, clopidogrel must undergo oxidation by hepatic P450 enzymes to its active form. This is significant because many drugs are metabolized the hepatic P450 enzymes, including statins, and clopidogrel may interact with these medications. Clopidogrel is a second-generation thienopyridine and ticlopidine is a first-generation thienopyridine. Both drugs are indicated in combination with aspirin to prevent stent thrombosis. Eptifibatide is a GPIIb-IIIa receptor antagonist that is used to treat unstable angina and non-ST segment elevation myocardial infarction.
Eptifibatide is also used to reduce ischemic events in patients who are undergoing percutaneous coronary intervention. The drug is a synthetic peptide that directly antagonizes the GPIIb-IIIa receptor on the platelet.
Aspirin is an antiplatelet drug that works by inhibition of synthesis of prostaglandins. Prostaglandin G2 is the result of a synthesis pathway that is activated by platelets and endothelial cells, and results in localized vasoconstriction and induction of platelet aggregation, as well as causing release of platelet granules. Warfarin is an anticoagulant that acts on vitamin K-dependent reactions in the coagulation pathway. Vitamin K is necessary for hepatic synthesis of coagulation factors II, VII, IX and X, protein C and protein S.
Vitamin K- dependent carboxylation is necessary for induction of enzymatic activity of these coagulation factors. Take- home message: Clopidogrel, a second-generation thienopyridine ADP receptor pathway inhibitor, is indicated in combination with aspirin to prevent stent thrombosis in patients who undergo percutaneous coronary intervention after myocardial infarction. Clopidogrel is a prodrug that must undergo oxidation by hepatic P450 enzymes, and therefore may affect the activity of statins and other drugs dependent on the hepatic P450 enzymes.

NEW QUESTION: 2
オンプレミスのデータセンターとAmazon VPC仮想プライベートゲートウェイの間にVPC VPN接続を確立するには、どのようなアクションが必要ですか？
A. メインルートテーブルを変更して、ネットワークアドレス変換インスタンスへのトラフィックを許可します。
B. AWS Direct Connectを使用して専用のネットワーク接続を確立します。
C. パブリックサブネットで専用のネットワークアドレス変換インスタンスを使用します。
D. 静的なインターネットルーティング可能なIPアドレスをAmazon VPCカスタマーゲートウェイに割り当てます。
Answer: B

NEW QUESTION: 3
A user reports browsing the Internet is slow and an icon with a picture of a person with a headset keeps asking them
to "click here for help." The user has clicked on the icon to try to resolve the slowness but all that happens is the
computer redirects them to a website to purchase software. Which of the following should be performed FIRST to
resolve the issue?
A. Identfy the type of malware
B. Train the user of malicious software
C. Run O/S updates
D. Create a restore point
Answer: A

NEW QUESTION: 4
A user is trying to access a popular email website but Is being redirected to a different website that asks for login credentials. The user calls a technician, who promptly notices a security issue. Which of the following should the technician do to remove the threat from the system?
A. Remove and reinstall the web browser In safe mode.
B. Remove all parameters after the FQDN website address
C. Remove all lines that are not comments from the hosts file
D. Remove all files from the temporary folder and restart the computer.
Answer: B